Run M1 CRC Challenge Assessment (SAMPLE 3) Spam protection, skip this field Assessor Name: Your name will be kept confidential to participants and any feedback you provide as an assessor will be forwarded anonymously. Email Address: Please note that your form can be saved so that you may later return to a partially completed form on the same device should you not be able to complete assessment of all participant results in a single sitting. Please ensure that you have cookies enabled in your browser and all ad-blockers disabled. Some hospital internet connection may block this save feature, so it may be worth it to test it out by completing the first couple of fields, scrolling down to the very bottom of the form to click the save button, closing your browser then re-opening the link. The below set of questions pertain to Sample 3: FARREL, JONATHAN (optional) Patient JF is a 66 year old man with advanced colorectal carcinoma and peritoneal carcinomatosis. He has received 6 cycles of FOLFIRI + panitumumab; however his oncologist notes worsening of his ascites and CT scans show definitive disease progression on therapy. A tumor sample is referred in for molecular testing to inform his next line of therapy. DOB: March 1, 1956 MRN: 34567 Lab 902 SAMPLE 3 1. Did the laboratory report the correct biomarker status? Yes No. An explanation below: REFERENCE RESULTS: MSS (MMR intact), BRAFV600E 2. Were the results received with enough time to deliver biomarker-informed treatment without interrupting patient flow? (i.e. would optimal treatment have been delayed at all due to the biomarker results?) Yes No. An explanation below: 3. What treatment would you prescribe to the patient in the vignette, based on the biomarker results provided by this lab? 4. Were the results easy to interpret? Yes No. An explanation below: 5. Did the participant comment on the following? Yes No Resistance to anti-EGFR monoclonal antibody therapy Yes No Sensitivity to BRAF TKI + anti-EGFR mAb Yes No 6. Additional comments or areas for improvement for the participant: Lab 903 SAMPLE 3 1. Did the laboratory report the correct biomarker status? Yes No. An explanation below: REFERENCE RESULTS: MSS (MMR intact), BRAFV600E 2. Were the results received with enough time to deliver biomarker-informed treatment without interrupting patient flow? (i.e. would optimal treatment have been delayed at all due to the biomarker results?) Yes No. An explanation below: 3. What treatment would you prescribe to the patient in the vignette, based on the biomarker results provided by this lab? 4. Were the results easy to interpret? Yes No. An explanation below: 5. Did the participant comment on the following? Yes No Resistance to anti-EGFR monoclonal antibody therapy Yes No Sensitivity to BRAF TKI + anti-EGFR mAb Yes No 6. Additional comments or areas for improvement for the participant: Lab 904 SAMPLE 3 1. Did the laboratory report the correct biomarker status? Yes No. An explanation below: REFERENCE RESULTS: MSS (MMR intact), BRAFV600E 2. Were the results received with enough time to deliver biomarker-informed treatment without interrupting patient flow? (i.e. would optimal treatment have been delayed at all due to the biomarker results?) Yes No. An explanation below: 3. What treatment would you prescribe to the patient in the vignette, based on the biomarker results provided by this lab? 4. Were the results easy to interpret? Yes No. An explanation below: 5. Did the participant comment on the following? Yes No Resistance to anti-EGFR monoclonal antibody therapy Yes No Sensitivity to BRAF TKI + anti-EGFR mAb Yes No 6. Additional comments or areas for improvement for the participant: Lab 905 SAMPLE 3 1. Did the laboratory report the correct biomarker status? Yes No. An explanation below: REFERENCE RESULTS: MSS (MMR intact), BRAFV600E 2. Were the results received with enough time to deliver biomarker-informed treatment without interrupting patient flow? (i.e. would optimal treatment have been delayed at all due to the biomarker results?) Yes No. An explanation below: 3. What treatment would you prescribe to the patient in the vignette, based on the biomarker results provided by this lab? 4. Were the results easy to interpret? Yes No. An explanation below: 5. Did the participant comment on the following? Yes No Resistance to anti-EGFR monoclonal antibody therapy Yes No Sensitivity to BRAF TKI + anti-EGFR mAb Yes No 6. Additional comments or areas for improvement for the participant: Lab 906 SAMPLE 3 1. Did the laboratory report the correct biomarker status? Yes No. An explanation below: REFERENCE RESULTS: MSS (MMR intact), BRAFV600E 2. Were the results received with enough time to deliver biomarker-informed treatment without interrupting patient flow? (i.e. would optimal treatment have been delayed at all due to the biomarker results?) Yes No. An explanation below: 3. What treatment would you prescribe to the patient in the vignette, based on the biomarker results provided by this lab? 4. Were the results easy to interpret? Yes No. An explanation below: 5. Did the participant comment on the following? Yes No Resistance to anti-EGFR monoclonal antibody therapy Yes No Sensitivity to BRAF TKI + anti-EGFR mAb Yes No 6. Additional comments or areas for improvement for the participant: Lab 907 SAMPLE 3 1. Did the laboratory report the correct biomarker status? Yes No. An explanation below: REFERENCE RESULTS: MSS (MMR intact), BRAFV600E 2. Were the results received with enough time to deliver biomarker-informed treatment without interrupting patient flow? (i.e. would optimal treatment have been delayed at all due to the biomarker results?) Yes No. An explanation below: 3. What treatment would you prescribe to the patient in the vignette, based on the biomarker results provided by this lab? 4. Were the results easy to interpret? Yes No. An explanation below: 5. Did the participant comment on the following? Yes No Resistance to anti-EGFR monoclonal antibody therapy Yes No Sensitivity to BRAF TKI + anti-EGFR mAb Yes No 6. Additional comments or areas for improvement for the participant: Lab 908 SAMPLE 3 1. Did the laboratory report the correct biomarker status? Yes No. An explanation below: REFERENCE RESULTS: MSS (MMR intact), BRAFV600E 2. Were the results received with enough time to deliver biomarker-informed treatment without interrupting patient flow? (i.e. would optimal treatment have been delayed at all due to the biomarker results?) Yes No. An explanation below: 3. What treatment would you prescribe to the patient in the vignette, based on the biomarker results provided by this lab? 4. Were the results easy to interpret? Yes No. An explanation below: 5. Did the participant comment on the following? Yes No Resistance to anti-EGFR monoclonal antibody therapy Yes No Sensitivity to BRAF TKI + anti-EGFR mAb Yes No 6. Additional comments or areas for improvement for the participant: Lab 901 SAMPLE 3 NOTE: (optional) Results were not submitted in time for assessment. Complete the questions below to the best of your abilities. 1. Did the laboratory report the correct biomarker status? Yes N/A No. An explanation below: REFERENCE RESULTS: MSS (MMR intact), BRAFV600E 2. Were the results received with enough time to deliver biomarker-informed treatment without interrupting patient flow? (i.e. would optimal treatment have been delayed at all due to the biomarker results?) Yes N/A No. An explanation below: 3. What treatment would you prescribe to the patient in the vignette, based on the biomarker results provided by this lab? 4. Were the results easy to interpret? Yes N/A No. An explanation below: 5. Did the participant comment on the following? Yes No N/A Resistance to anti-EGFR monoclonal antibody therapy Yes No N/A Sensitivity to BRAF TKI + anti-EGFR mAb Yes No N/A 6. Additional comments or areas for improvement for the participant: Save draft